食品工业科技2026，Vol.47Issue(11)：44-56,13.DOI:10.13386/j.issn1002-0306.2025070331
金寨白叶与福鼎寿眉化学谱及抗慢性溃疡性结肠炎功效比较
Comparative Investigation of the Chemical Profiles and Anti-chronic Ulcerative Colitis Effects of Jinzhai Baiye and Fuding Shoumei White Tea
摘要
Abstract
The characteristic chemical composition and healthy function of Jinzhai Baiye(JZ)and Fuding Shoumei(FD)were unknown.In this study,two white teas were comparatively evaluated in terms of their characteristic chemical compo-sition and anti-DSS induced colitis.The non-volatile chemical constituents between JZ and FD white teas were systemati-cally profiled by using un-targeted metabolomics analysis based on UHPLC-Q-Orbitrap-MS/MS approach.Then,anti-colitis of two white teas was explored based on recently developed DSS-induced chronic colitis model.The results showed that there were significant differences in chemical constituents between JZ and FD white teas.A total of 51 compounds with sig-nificant differences between two white teas were identified,including catechins,flavonoid glycosides,amino acids,pheno-lic acids,lipids.Among them,the contents of some catechins,flavonoid glycosides(rutin,kaempferol 3-O-arabinoglyco-side,quercetin-3-galactoside),amino acids(theanine,arginine)were relatively high in FD.While the contents of some flavonoid glycosides(vitexin,kaempferol,3-(6-acetylgalactoside))and majority of phenolic acids were relatively high in JZ.After 4 cycles of 2%DSS induction,DSS group exhibited chronic syndrome of ulcerative colitis,showing significant decrease in body weight with an obvious undulating trend(P<0.001),shorten colon length,significant increase of DAI scores and splenic index(P<0.001).However,intervention with both JZ and FD significantly improved the syndrome of DSS-induced ulcerative colitis.Interestingly,JZ showed better protective effects than that of FD.Real-Time PCR data revealed that both JZ and FD significantly suppressed the major inflammatory cytokines gene expression,and increased anti-inflammatory cytokine IL-10 expression.JZ proved better anti-inflammatory effects than that of FD.This study provided the characteristic chemical compounds and their anti-inflammatory effects on DSS induced ulcerative colitis between the two white teas,which provided a basis for evaluating the chemical quality and potential health function of JZ white tea.关键词
金寨白叶/福鼎寿眉/非靶向代谢组学/差异化学成分/慢性溃疡性结肠炎Key words
Jinzhai Baiye white tea/Fuding Shoumei white tea/non-targeted metabolomics/differentiated chemical compounds/chronic ulcerative colitis分类
医药卫生引用本文复制引用
周丽伟,肖艳,郭慧敏,陈辉,解正定,谢忠稳..金寨白叶与福鼎寿眉化学谱及抗慢性溃疡性结肠炎功效比较[J].食品工业科技,2026,47(11):44-56,13.基金项目
国家重点研发计划(2021YFD1601102) （2021YFD1601102）
金寨县茶产业发展基金(KJ2022589) （KJ2022589）
国家自然科学基金区域发展联合基金(U19A2034). （U19A2034）
