食品工业科技2026，Vol.47Issue(11)：88-99,12.DOI:10.13386/j.issn1002-0306.2025040227
基于网络药理学与分子对接研究不同药食同源植物提取液的降脂作用
Hypolipidemic Effects of Medicinal and Edible Plant Extracts Based on Network Pharmacology and Molecular Docking
摘要
Abstract
To investigate the active components and hypolipidemic effects of medicinal and edible plants,this study evalu-ated eight species(foxtail millet,coix seed,tangerine peel,hawthorn,lotus leaf,mulberry leaf,cassia seed,and ginseng)through quantitative analysis of bioactive compounds,antioxidant capacity,and lipid metabolism-related functional indices,followed by cluster analysis and principal component analysis.Network pharmacology and molecular docking were further employed to identify potential hypolipidemic targets and pathways.Results demonstrated that lotus leaf exhibited the high-est flavonoid(75.81±2.87 mg RE/g DW)and total phenolic content(38.63±0.88 mg GAE/g DW),while hawthorn showed the highest total sugar content(67.54±1.13 mg DE/g DW).Notably,hawthorn displayed potent inhibitory effects on pancre-atic lipase(1.59±0.04 μg Orlistat/g DW),α-amylase(4.26±0.23 mg Acarbose/g DW),and α-glucosidase(87.46±0.97 μg Acarbose/g DW),along with superior sodium glycocholate binding capacity(59.24%)and cholesterol adsorption(9.57 mg/g).Network pharmacology revealed that hawthorn,lotus leaf,and coix seed primarily targeted lipid metabolism and atheroscle-rosis pathways,particularly through insulin resistance regulation.Molecular docking simulations revealed that key bioac-tive compounds(including stigmasterol,sitosterol,and rutin)exhibited strong binding affinities with core targets(INS,ALB,IL-6,etc.).These findings highlight hawthorn,lotus leaf,and coix seed as promising candidates for developing natu-ral hypolipidemic functional foods,supported by multi-omics evidence.关键词
药食同源/活性成分/降脂/分子对接/网络药理学分析Key words
medicine food homology/active ingredient/lipid-lowering/molecular docking/network pharmacology analysis分类
轻工纺织引用本文复制引用
张惠,张灵芝,张鑫,王远亮,肖愈,孔文平..基于网络药理学与分子对接研究不同药食同源植物提取液的降脂作用[J].食品工业科技,2026,47(11):88-99,12.基金项目
湖南省教育厅科学研究重点项目(24A0158) （24A0158）
江西省自然科学基金项目(20252BAC200576). （20252BAC200576）
