食品与发酵工业2026，Vol.52Issue(10)：407-419,13.DOI:10.13995/j.cnki.11-1802/ts.043874
微生物合成谷氨酸及其衍生物的研究进展
Research progress on biosynthesis of glutamic acid and its derivatives
摘要
Abstract
Glutamic acid stands among the most abundant amino acids in nature.Beyond its role in composing biological proteins,it serves as a central node within metabolic networks.Glutamic acid and its derivatives(glutathione,L-theanine,γ-aminobutyric acid,glu-tamine,γ-polyglutamic acid),recognized as high-value biochemical products,find extensive applications across food,pharmaceutical,and materials industries.Recent advances in synthetic biology and systems metabolic engineering have driven significant breakthroughs in the biosynthesis of glutamic acid and its derivatives.This article focuses on the biosynthesis of glutamic acid and its derivatives,systemati-cally reviews the latest important research progress,provides reference for scientific research and industrialization in related fields,and looks forward to the development prospects of glutamic acid and its derivatives.关键词
谷氨酸/谷胱甘肽/L-茶氨酸/γ-氨基丁酸/谷氨酰胺/γ-聚谷氨酸Key words
glutamic acid/glutathione/L-theanine/γ-aminobutyric acid/glutamine/γ-polyglutamic acid引用本文复制引用
关丹,张迪,乔郅钠,尤甲甲,高敏杰,黄子洋,饶志明..微生物合成谷氨酸及其衍生物的研究进展[J].食品与发酵工业,2026,52(10):407-419,13.基金项目
国家重点研发计划项目(2021YFC2100900) （2021YFC2100900）
江苏省前沿技术研发计划项目(BF2024012) （BF2024012）
国家自然科学基金项目(32471530) （32471530）
呼和浩特市"揭榜挂帅"项目(2023-揭榜挂帅-合-1) （2023-揭榜挂帅-合-1）
