食品与发酵工业2026，Vol.52Issue(11)：74-80,7.DOI:10.13995/j.cnki.11-1802/ts.044047
活性肽复合物对慢性酒精性肝损伤小鼠的保护作用及机制
Protective effect and mechanism of active peptide complex on chronic alcoholic liver injury in mice
摘要
Abstract
To explore natural and novel functional foods for the prevention and treatment of chronic alcoholic liver injury(CALI),three novel active peptides complexes were developed through rational formulation.Their regulatory effects on liver protection,and inflam-mation in CALI mice were evaluated,and the underlying mechanisms involving oxidative stress,lipid metabolism,and gut microbiota modulation were investigated.Results showed that all three peptide complexes,particularly the concentrated formulation,effectively allevi-ated alcohol-induced behavioral changes in CALI mice.They significantly enhanced hepatic alcohol dehydrogenase(ADH)and acetalde-hyde dehydrogenase(ALDH)activities,reduced liver index,and lowered serum levels of alanine aminotransferase(ALT)and aspartate aminotransferase(AST),thereby improving hepatic histopathological damage.Moreover,these complexes downregulated hepatic TNF-αand IL-6 levels,while increasing superoxide dismutase,catalase,and glutathione contents,and reducing malondialdehyde levels.Addi-tionally,they improved lipid profiles,including total cholesterol and triglycerides,and enhanced gut microbiota diversity and abundance.These findings provide a scientific basis for the development of novel functional foods with hepatoprotective and alcohol-metabolism-enhan-cing properties.关键词
慢性酒精性肝损伤/活性肽/氧化应激/酒精代谢/肝脏保护/肠道菌群Key words
chronic alcoholic liver injury/active peptide/oxidative stress/alcohol metabolism/hepatoprotection/gut microbiota引用本文复制引用
魏炳琦,陈柳,张剑平,郝在林,刘延鑫..活性肽复合物对慢性酒精性肝损伤小鼠的保护作用及机制[J].食品与发酵工业,2026,52(11):74-80,7.基金项目
河南省中医药科学研究专项重点项目(2024ZY1030) （2024ZY1030）
河南中医药大学横向课题(202400008) （202400008）
