中国食品添加剂2026，Vol.37Issue(6)：1-12,12.DOI:10.19804/j.issn1006-2513.2026.6.001
新型甜味剂紫苏葶的系统性毒理学评价及安全性研究
Systematic toxicological evaluation and safety assessment of perillartine as a novel sweetener
摘要
Abstract
In order to comprehensively assess the safety of perillartine,this study performed acute,subacute and genotoxicity tests.The results showed that:the acute oral LD50 of perillartine was 765.242 mg/kg,which was classified as low toxicity.No significant toxicity was observed in the 28-day subacute study.In the bacterial reverse mutation assay,perillartine showed potential mutagenicity toward Escherichia coli WP2 UvrA at a high concentration(1000 μg/plate)but was not mutagenic to the four Salmonella typhimurium strains tested.In the mouse spermatogonial assay,no increase in chromosomal aberrations was found at doses of 1/2,1/4,or 1/8 of the LD50.In conclusion,the overall safety profile of perillartine was considered to be favorable under the experimental conditions of this study.However,its potential mutagenicity towards Escherichia coli WP2 UvrA at high concentrations in vitro warrants attention regarding its biological effects at high doses.关键词
紫苏葶/毒性/急性毒性/亚急性毒性/遗传毒性/甜味剂Key words
perillartine/toxicity/acute toxicity/subacute toxicity/genotoxicity/sweetener分类
轻工纺织引用本文复制引用
蒋家帅,陈璇,朱柯翰,刘思捷,夏赞贤,朱里鹏..新型甜味剂紫苏葶的系统性毒理学评价及安全性研究[J].中国食品添加剂,2026,37(6):1-12,12.基金项目
国家自然科学基金项目(32571465、U21A20384和82502544) （32571465、U21A20384和82502544）
湖南省科技创新计划(创新平台与人才计划)-外国专家项目(2024WZ9001) （创新平台与人才计划）
北京生命科技研究院有限公司重点项目(2024100CB0170和2024200CD0020) （2024100CB0170和2024200CD0020）
