中国酿造2026，Vol.45Issue(7)：68-79,12.DOI:10.11882/j.issn.0254-5071.2026.07.009
玉米须发酵液对2型糖尿病小鼠糖脂代谢的调节作用
Regulatory Effect of Corn Silk Fermentation Liquid on Glucose and Lipid Metabolism in Type 2 Diabetic Mice
摘要
Abstract
To explore the hypoglycemic effect of corn silk fermentation liquid(CSFL)on diabetic mice and its underlying mechanism,a type 2 diabetic mouse model was induced by a high-fat diet combined with streptozotocin.The effects of different doses of CSFL on glucose and lipid metabolism,liver function,histopathology,and intestinal microbiota composition were examined.The results showed that CSFL reduced food and water intake of diabetic mice to varying degrees.Compared with the model group,the high-dose CSFL group exhibited significant reductions in fasting blood glucose(FBG),total cholesterol,and low-density lipoprotein cholesterol(P<0.001),along with a significant improvement in glucose tolerance(P<0.001).The activity of catalase was markedly elevated(P<0.05).Both high-and low-dose CSFL groups showed significant increases in glutathione peroxidase activity(P<0.001),significant reduction in malondialdehyde content(P<0.01,P<0.001),and significant decreases in aspartate aminotransferase activity(P<0.05).In both CSFL groups,the liver index was significantly increased(P<0.001),while no significant differences were observed in the pancreas,kidney,or spleen indices(P>0.05).CSFL administration effectively alleviated pathological changes such as hepatic steatosis and pancreatic islet cell damage.Compared with the model group,the high-dose CSFL group significantly increased the Chao1,Simpson,and Shannon indices of the gut microbiota(P<0.05,P<0.01).CSFL administration decreased the relative abundance of Bacteroidota and increased the relative abundance of Verrucomicrobiota and Akkermansia in the gut of diabetic mice.The contents of acetic acid,propionic acid,butyric acid,and isobutyric acid in mouse feces were significantly increased by CSFL(P<0.05,P<0.001).In conclusion,CSFL can regulate glucose and lipid metabolism,strengthen antioxidant capacity and remodel intestinal microbiota in a dose-dependent manner,indicating its potential for development as a natural hypoglycemic product.关键词
玉米须发酵液/2型糖尿病/糖脂代谢/氧化应激/肠道菌群Key words
corn silk fermentation liquid/type 2 diabetes mellitus/glucose and lipid metabolism/oxidative stress/gut microbiota分类
轻工纺织引用本文复制引用
褚佳盈,刘晓兰,郑喜群,姜彩霞,王俊彤,黎奇伟..玉米须发酵液对2型糖尿病小鼠糖脂代谢的调节作用[J].中国酿造,2026,45(7):68-79,12.基金项目
中央引导地方科技发展专项(ZY23QY06) （ZY23QY06）
黑龙江省"百千万"工程科技重大专项(2021ZX12B09-4) （2021ZX12B09-4）
黑龙江省自然科学基金项目(YQ2020C036) （YQ2020C036）
黑龙江八一农垦大学学成、引进人才科研启动计划项目(XYB201916) （XYB201916）
