食品科学2026，Vol.47Issue(14)：17-30,14.DOI:10.7506/spkx1002-6630-20260112-095
六安瓜片-决明子-枸杞复配改善代谢功能障碍相关脂肪性肝病效应
Combination of Lu'an Guapian Tea,Cassiae Semen and Lycium barbarum Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease
摘要
Abstract
To systematically explore the mechanism underpinning the influence of combination of Lu'an Guapian tea,Cassiae Semen and Lycium barbarum on glycolipid metabolism,this study initially identified 32 core functional targets associated with metabolic dysfunction-associated steatotic liver disease(MASLD)for these three ingredients using the TCMSP,PharmMapper,and GeneCards databases.Gene Ontology(GO)functional and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed using the DAVID database,which revealed significant enrichment of these targets in pathways such as diabetic cardiomyopathy,lipid and atherosclerosis,and insulin resistance(IR).A"drug-component-target-pathway"four-dimensional network was further constructed and analyzed topologically.The findings suggested that epigallocatechin gallate and epigallocatechin may be the principal active compounds responsible for ameliorating MASLD.Additionally,molecular docking analyses revealed that these active constituents interacted with key targets(insulin receptor(INSR),AKT serine/threonine kinase 1(AKT1),glycogen synthase kinase-3 beta(GSK3β),protein tyrosine phosphatase non-receptor type 1(PTPN1))in the IR signaling pathway primarily through hydrogen bonding and hydrophobic interactions.A HepG2 cell model of IR was employed to assess the hypoglycemic and lipid-lowering effects of combinations at different ratios.The results indicated that combination of Lu'an Guapian tea,Cassiae Semen,and L.barbarum at 1:1:2 exhibited the most significant hypoglycemic activity,whereas their 2:1:1 combination showed the best lipid-lowering efficacy.This study provides a theoretical foundation for the development of functional plant-based formulations.关键词
六安瓜片/决明子/枸杞/代谢功能障碍相关脂肪性肝病/胰岛素抵抗/糖脂代谢Key words
Lu'an Guapian tea/Cassiae Semen/Lycium barbarum/metabolic dysfunction-associated steatotic liver disease/insulin resistance/glucose and lipid metabolism分类
轻工纺织引用本文复制引用
周思梦,祝尚良,褚为荣,朱雨婷,王红燕,王一君,谢忠稳,李大祥,葛慧芳..六安瓜片-决明子-枸杞复配改善代谢功能障碍相关脂肪性肝病效应[J].食品科学,2026,47(14):17-30,14.基金项目
安徽省教育厅自然科学青年项目(2025AHGXZK40503) （2025AHGXZK40503）
安徽农业大学高层次人才引进项目(rc352211) （rc352211）
大健康研究院食品营养健康联合研究中心专项资金资助项目(2023SJY02 （）
2024SJY02) （）
现代农业产业技术体系建设专项(CARS-19) （CARS-19）
