食品与发酵工业2026，Vol.52Issue(15)：72-80,9.DOI:10.13995/j.cnki.11-1802/ts.043914
胰脏酶解物改善脂多糖诱导的大鼠全身性炎症的研究
Study on the improvement of lipopolysaccharide-induced systemic inflammation in rats by pancreatic enzymatic hydrolysate
刘任营 1李玉慧 1刘馨雅 1张羽佳 1路福平 1王海宽1
作者信息
- 1. 天津科技大学生物工程学院,天津,300457
- 折叠
摘要
Abstract
Inflammation is a critical biological response to harmful stimuli,but chronic inflammation can lead to severe diseases such as cardiovascular disorders,diabetes,and cancer.This study explores the anti-inflammatory potential of bioactive peptides derived from porcine pancreatic hydrolysate,in a lipopolysaccharide(LPS)-induced systemic inflammation model in rats.Porcine pancreas,rich in proteins,was enzymatically hydrolyzed using papain to generate bioactive peptides.Rats were divided into protective and therapeutic inter-vention groups,receiving low(0.19 g/kg),medium(0.57 g/kg),and high(0.95 g/kg)doses of pancreatic hydrolysate before or after LPS challenge.Blood samples were collected after treatment,and inflammatory factors were assayed using ELISA kits.Histological analysis of colon tissues was performed using H&E.Results demonstrated that pancreatic hydrolysate significantly reduced pro-inflammatory cyto-kine levels in a dose-dependent manner,with the high-dose group showing the most pronounced effects.Protective intervention was more effective than therapeutic intervention in mitigating inflammation and preserving colonic morphology.This study highlights the potential of porcine pancreatic hydrolysate as a natural anti-inflammatory agent,offering a sustainable solution for valorizing meat industry by-prod-ucts.关键词
抗炎肽/猪胰腺水解物/脂多糖/全身炎症反应综合征Key words
anti-inflammatory peptides/porcine pancreatic hydrolysate/lipopolysaccharide(LPS)/systemic inflammatory response syn-drome(SIRS)引用本文复制引用
刘任营,李玉慧,刘馨雅,张羽佳,路福平,王海宽..胰脏酶解物改善脂多糖诱导的大鼠全身性炎症的研究[J].食品与发酵工业,2026,52(15):72-80,9.
