乳业科学与技术2026，Vol.49Issue(4)：12-19,8.DOI:10.7506/rykxyjs1671-5187-20260312-022
乳源益生菌调控2型糖尿病的分子机制与应用研究进展
Recent Advances in the Molecular Mechanisms and Application of Milk-Derived Probiotics in the Management of Type 2 Diabetes Mellitus
摘要
Abstract
The global prevalence of type 2 diabetes mellitus(T2DM)is closely associated with an imbalance in the gut microbiota.The molecular mechanisms by which milk-derived probiotics regulate the gut microbiota and improve host metabolism have attracted significant attention.This review summarizes the core mechanisms by which milk-derived probiotics interact with the host to improve T2DM.Specifically,probiotics repair the intestinal barrier and reshape the microbial community structure,producing metabolites such as short-chain fatty acids and secondary bile acids.These metabolites subsequently activate key molecular targets,including G protein-coupled receptors 41/43 and farnesoid X receptor,ultimately alleviating peripheral insulin resistance in the host and protecting pancreatic β-cell function.Furthermore,this paper reviews recent research on the application of probiotics,including screening for functional strains based on hypoglycemic mechanisms and microencapsulation.By elucidating the interaction mechanisms between probiotics and the host,this study aims to provide a theoretical foundation and practical guidance for the development of precision prevention and treatment strategies for T2DM based on milk-derived probiotics.关键词
乳源益生菌/2型糖尿病/糖脂代谢/肠道菌群/短链脂肪酸Key words
milk-derived probiotics/type 2 diabetes mellitus/glucolipid metabolism/gut microbiota/short-chain fatty acids分类
轻工纺织引用本文复制引用
巴合班·叶尔江,刘学莲,热孜亚·别尔迪木拉提,塔布斯·马那尔,新华·那比..乳源益生菌调控2型糖尿病的分子机制与应用研究进展[J].乳业科学与技术,2026,49(4):12-19,8.基金项目
国家自然科学基金地区科学基金项目(82260640) （82260640）
