乳业科学与技术2026，Vol.49Issue(4)：45-50,6.DOI:10.7506/rykxyjs1671-5187-20260306-018
唾液链球菌嗜热亚种BD9818安全性及其后生元助睡眠功效分析
Safety of Streptococcus salivarius subsp.thermophilus BD9818 and Sleep-Promoting Effect of Its Postbiotic
摘要
Abstract
In this study,Streptococcus salivarius subsp.thermophilus BD9818,isolated from koumiss,was evaluated for its safety via hemolytic activity assay and animal pathogenicity test,and the sleep-improving effect of its postbiotic was investigated using a zebrafish model of insomnia.The results demonstrated that strain BD9818 was non-hemolytic and exhibited no pathogenicity in animals,thus confirming its safety for application.Furthermore,low(250 μg/mL),medium(500 μg/mL),and high(1 000 μg/mL)doses of the postbiotic BD9818 all significantly reduced the awakening activity(P<0.01,P<0.01,and P<0.001)and total awakening time(P<0.05,P<0.01,and P<0.001)of zebrafish,while significantly up-regulating the expression level of the gabra1 gene(P<0.05 for the low and medium doses,P<0.01 for the high dose group).In conclusion,strain BD9818 is safe for consumption,and its postbiotic possesses favorable sleep-improving activity.关键词
唾液链球菌嗜热亚种BD9818/后生元/安全性评价/致病性/改善睡眠Key words
Streptococcus salivarius subsp.thermophilus BD9818/postbiotics/safety evaluation/pathogenicity/sleep improvement分类
轻工纺织引用本文复制引用
贾宏信,苏米亚..唾液链球菌嗜热亚种BD9818安全性及其后生元助睡眠功效分析[J].乳业科学与技术,2026,49(4):45-50,6.基金项目
上海市国资委企业创新发展和能级提升项目(2022013) （2022013）
