乳业科学与技术2026，Vol.49Issue(4)：60-66,7.DOI:10.7506/rykxyjs1671-5187-20260306-021
特殊医学用途配方食品中45种全氟化合物高通量检测
High-Throughput Detection of 45 Per-and Polyfluoroalkyl Substances in Foods for Special Medical Purposes
摘要
Abstract
This study aims to establish a rapid and quantitative method for the detection of 45 per-and polyfluoroalkyl substances(PFAS)in foods for special medical purposes using ultra-performance liquid chromatography-quadrupole-time of flight-tandem mass spectrometry.Samples were extracted with acetonitrile.Chromatographic separation was performed on a ZORBAX RRHD Eclipse Plus C18 column(2.1 mm×100 mm,1.8 μm)using gradient elution a mobile phase composed of a 50%acetonitrile in methanol and 20 mmol/L ammonium acetate aqueous solution containing 0.1%formic acid.Detection was carried out in high-resolution multiple reaction monitoring mode.The results showed that calibration curves for all analytes exhibited good linearity over the concentration range of 1-500 ng/mL.All 45 PFAS compounds showed precise mass relative errors within 5.0×10-6.The method's limit of detection(LOD)ranged from 2.5 to 125 ng/g,and its limit of quantitation(LOQ)was 5-250 ng/g.At spiked levels of 5-2 500 ng/g,recoveries ranged from 70.58%to 116.67%,with relative standard deviations(RSDs)below 15%.All experimental results met the requirements for the quantitative analysis of trace contaminants in food matrices.关键词
超高效液相色谱-四极杆-飞行时间-串联质谱/特殊医学用途配方食品/全氟化合物/快速筛查/定量分析Key words
ultra-high performance liquid chromatography-quadrupole-time of flight-tandem mass spectrometry/foods for special medical purposes/per-and polyfluoroalkyl substances/rapid screening/quantitative analysis分类
化学化工引用本文复制引用
张明星,杨层层,马俊美..特殊医学用途配方食品中45种全氟化合物高通量检测[J].乳业科学与技术,2026,49(4):60-66,7.基金项目
国家市场监督管理总局科技计划项目(S2025MK0622) （S2025MK0622）
