食源性纳米二氧化钛对生物体肠道功能及糖脂代谢的影响OACSCD
Effects of Food-derived Titanium Dioxide Nanoparticles on Intestinal Function and Glycolipid Metabolism of Organisms
随着纳米技术的不断发展,人们不可避免地通过各种途径接触纳米材料.纳米二氧化钛(TiO2 NPs)作为纳米金属氧化物材料家族的典型代表,因良好的增白和抗结性能,故作为食品添加剂广泛应用于食品领域.由于TiO2 NPs尺寸较小、比表面积较大,进入机体后可穿过肠道屏障,进入血液循环并在脏器内沉积,影响各部位细胞生理功能,最终引起机体代谢紊乱,这使得人们越发关注TiO2 NPs对生物体肠道功能及糖脂代谢造成的不利影响.本文总结饮食摄入TiO2 NPs后对机体肠道结构、消化吸收功能、肠道菌群的影响,同时探讨其对糖脂代谢的影响以及分子调控机制,以期为治疗由食源性TiO2 NPs引起的肠道疾病、糖脂代谢紊乱,以及规范TiO2 NPs的安全使用剂量提供参考.
With the continuous development of nanotechnology,people inevitably come into contact with nanomaterials through various pathways.Titanium dioxide nanoparticles(TiO2 NPs)as a typical representative of nano-metal oxide ma-terials family,has been widely used as food additives in the food industry field due to their good whitening and anti-caking properties.Because of its small size and large specific surface area,could pass through the intestinal barrier,then enter the blood circulation and deposit in the organs in the end.Thereby affecting the physiological functions of cells in various parts,and causing metabolic disorders in the body,which makes people pay more and more attention to the adverse effects of TiO2 NPs about the intestinal health and glucolipid metabolism of organisms.Therefore,this review summarized the effects of TiO2 NPs on intestinal structure,digestion and absorption function and intestinal flora,and the effects of TiO2 NPs on glucose and lipid metabolism and its molecular regulation mechanism were also discussed,which aimed to provide a reference for the treatment of intestinal diseases and disorders of glucolipid metabolism caused by food-borne TiO2 NPs,as well as the regulation of the safe dosage of TiO2 NPs.
刘静怡;钟亮;袁甜甜;孙敬春;杨公社;于太永
西北农林科技大学动物科技学院 陕西杨凌 712100
纳米二氧化钛肠道功能糖脂代谢安全性
titanium dioxide nanoparticlesintestinal functionglucolipid metabolismsafety
《中国食品学报》 2023 (011)
394-402 / 9
陕西省畜禽育种两链融合重点专项(2022GD-TSLD-46)
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