食品工业科技2024，Vol.45Issue(3)：310-319,10.DOI:10.13386/j.issn1002-0306.2023020048
乳提技术提高干姜提取物生物利用度及其抗炎活性研究
Milk-Based Extraction Technology Enhances the Bioavailability and Anti-inflammatory Activity of Ginger Extract
马真 1徐军 2邬娟 2王彩云 3何剑 4敬璞1
作者信息
- 1. 上海交通大学农业与生物学院,上海 200240||上海交通大学四川研究院,四川成都 610000
- 2. 内蒙古乳业技术研究院有限责任公司,内蒙古呼和浩特 010080||伊利伊诺科技(上海)有限责任公司,上海 201111
- 3. 内蒙古乳业技术研究院有限责任公司,内蒙古呼和浩特 010080||国家乳业技术创新中心,内蒙古呼和浩特 010080
- 4. 伊利伊诺科技(上海)有限责任公司,上海 201111||国家乳业技术创新中心,内蒙古呼和浩特 010080
- 折叠
摘要
Abstract
This study was conducted to evaluate the bioavailability and anti-inflammatory efficacy of ginger milk extract through cell and animal experiments compared with commercial ginger water extract.High-performance liquid chromatography was used to analyze the contents of ginger phenols in ginger extract.The bioavailability of ginger milk extract in Caco-2 model and its effect on ulcerative colitis in rats were evaluated.The results showed that the content of 6-gingerol,the active component in ginger,was increased by 13.1%in ginger milk extract than that in the water extract.The total phenols in ginger milk extract were more easily absorbed by Caco-2 cells than that in the water extract,increasing by 34.9%after 24 hours of culture.Compared with ginger water extract,ginger milk extract significantly reduced the decline of body mass,DAI score,alleviate colon atropymass,and spleen index of colitis rats.The expression level of TNF-α,IL-1β,IL-6 in colon tissue significantly decreased(P<0.05).The activity of superoxide dismutase(SOD)was increased,and the content of malondialdehyde(MDA)was significantly decreased(P<0.05).The results showed that ginger milk extract showed better bioavailability and effectively relieve the symptoms of ulcerative colitis in rats induced by sodium glucan sulfate.The experimental results could provide theoretical reference for the efficient extraction of ginger active ingredients and the development of functional food.关键词
干姜乳提物/乳提技术/Caco-2细胞吸收/溃疡性结肠炎Key words
ginger milk extract/milk-based extraction technology/Caco-2 cell absorption/ulcerative colitis分类
轻工纺织引用本文复制引用
马真,徐军,邬娟,王彩云,何剑,敬璞..乳提技术提高干姜提取物生物利用度及其抗炎活性研究[J].食品工业科技,2024,45(3):310-319,10.
