金属有机框架化合物ZIF-8基于QuEChERS-GC-MS/MS测定禽蛋中21种有机磷农药OACSTPCD

To establish a method for the determination of 21 organophosphorus pesticide residues in poultry eggs by modified QuEChERS pretreatment and gas chromatography-tandem mass spectrometry(GC-MS/MS).The samples were extracted with acetonitrile,purified by metal-organic framework material-ZIF-8,and analyzed by GC-MS/MS.HP-5ms column was used for the separation,and the electron bombardment ion source(EI)was employed with multiple reaction monitoring(MRM)mode for the detection.The matrix matched external standard calibration curves were used for quantitative analysis.The results indicated that the instrument limit of detection(LOD)for 21 organophosphorus pesticides were 0.1〜5.6 µg/kg,and the limit of quantification(LOQ)was 0.3〜9.6 µg/kg.The correlation coefficient(R2)of the calibration curves for the compounds was above 0.9959.The average recoveries of 21 organophosphorus pesticides in poultry eggs at three spiked levels(10、20 and 40 µg/kg)were 85.9%〜118.0%(n=6),the relative standard deviations(RSDs)was 1.3%〜5.2%.The method was rapid,sensitive and accurate.It has a good application prospect in the detection of organochlorine and organophosphorus pesticide residues in various poultry eggs.