多酚自组装抗菌生物材料的构建及其应用进展OA北大核心CSTPCD

Bacterial infection,a leading cause of global mortality,can result in various diseases.While antibiotics are the primary treatment for infections,their excessive and irrational use has led to the emergence of a variety of bacterial drug resistance,posing a serious threat to human health.Plant polyphenols have natural antibacterial properties,but the instability of the phenolic hydroxyl structure limits their bioavailability.To solve this problem,researchers have explored the self-assembly of polyphenols with other substances to construct new nano-biomaterials.These biomaterials not only enhance the stability and bioavailability of polyphenols but also exhibit synergistic antibacterial activity,showing a great promise in the field of antibacterial applications.This review examined the construction strategies and antibacterial properties of different types of polyphenol self-assembled biomaterials developed in recent years,including polyphenol-metal,polyphenol-hydrogel,polyphenol-chitosan,polyphenol-protein and polyphenol-liposome.Furthermore,the challenges and future prospects of the novel polyphenol self-assembling biomaterials in the field of antibacterial application were discussed.