可注射奥沙利铂缓释微粒制备及其理化性质研究OA北大核心CSTPCD

Objective:Injectable oxaliplatin sustained-release microparticles were developed,and their preparation process and physical and chemical properties were studied.Methods:Injectable oxaliplatin sustained-release microparticles were prepared by hot melt extrusion freeze grinding process.The morphology and particle size distribution of the sustained-release microparticles were studied by scanning electron microscope and particle size analyzer.The content of oxaliplatin in the sustained-release mic-roparticles and the release of microsome were measured by liquid chromatography system.Results:The particle size distribution curve of injectable oxaliplatin sustained-release microparticles was stable,and the encapsulation efficiency of oxaliplatin in the mic-roparticles was 46.8%,which was high.The results of in vitro release showed that the release period of oxaliplatin sustained-re-lease microparticles was 144 hours,and the final release degree was above 80.0%,with sustained release performance.The pH value of the sustained-release microparticles injection is within the range of 6.18-6.45,and it will not cause damage to the injection site.Conclusion:Injectable oxaliplatin sustained-release microparticles prepared by hot melt extrusion freeze grinding process have uniform particle size distribution,high drug encapsulation efficiency,excellent slow and controlled release characteristics and sta-ble physical and chemical properties.