可注射奥沙利铂缓释微粒制备及其理化性质研究OA北大核心CSTPCD
Preparation and physicochemical properties of injectable oxaliplatin sustained-release microparticles
目的:开发可注射奥沙利铂缓释微粒,并对其制备工艺和理化性质进行研究.方法:采用热熔挤出-冷冻研磨工艺制备可注射奥沙利铂缓释微粒,使用扫描电镜、粒度分析仪了解微粒形貌及粒径分布,采用液相色谱系统测量缓释微粒中奥沙利铂含量和微粒体外释放度.结果:可注射奥沙利铂缓释微粒粒度分布曲线稳定,微粒中奥沙利铂包封率为46.8%,包封率高;体外释放结果显示,奥沙利铂缓释微粒释放周期为144 h,最终释放度在80.0%以上,具有缓释性能;缓释微粒注射剂pH值在6.…查看全部>>
Objective:Injectable oxaliplatin sustained-release microparticles were developed,and their preparation process and physical and chemical properties were studied.Methods:Injectable oxaliplatin sustained-release microparticles were prepared by hot melt extrusion freeze grinding process.The morphology and particle size distribution of the sustained-release microparticles were studied by scanning electron microscope and particle size analyzer.The content of oxal…查看全部>>
张俊伟;焦斌琪;曹坤;张彦志;陈铭哲;黄克祥;梁月祥;李井泉
海南医学院第一附属医院胃肠肿瘤外科,海南 海口 570100海南医学院第一附属医院胃肠肿瘤外科,海南 海口 570100海南医学院第一附属医院胃肠肿瘤外科,海南 海口 570100海南医学院第一附属医院胃肠肿瘤外科,海南 海口 570100海南医学院第一附属医院胃肠肿瘤外科,海南 海口 570100海南医学院第一附属医院胃肠肿瘤外科,海南 海口 570100海南医学院第一附属医院胃肠肿瘤外科,海南 海口 570100海南医学院第一附属医院胃肠肿瘤外科,海南 海口 570100
化学工程
可注射奥沙利铂缓释微粒制备工艺理化性质
Injectable oxaliplatin sustained-release microparticlesPreparation processPhysical and chemical properties
《海南医学院学报》 2024 (10)
779-783,5
This study was supported by Key Research and Development Project of Hainan Provincial Science and Technology Department(ZDYF2020137) 海南省科学技术厅重点研发项目(ZDYF2020137)
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