孕期传统和新兴真菌毒素暴露的胚胎发育毒性及其生物监测的研究现状OA北大核心CSTPCD
Research Status of Embryonic Developmental Toxicity and Biological Monitoring of Exposure to Traditional and Emerging Mycotoxins during Pregnancy
真菌毒素是某些真菌菌种在特定条件下产生的有毒次级代谢产物.研究发现多种真菌毒素的联合暴露可引起胎儿发育迟缓、胚胎停育甚至流产等胚胎发育毒性.目前,尚没有关于孕期真菌毒素暴露对宫内胎儿胚胎发育毒性的影响和生物监测情况的系统报道.因此,为预防和降低孕期真菌毒素暴露带来的危害,本文梳理了孕期传统真菌毒素如黄曲霉毒素、脱氧雪腐镰刀菌烯醇、玉米赤霉烯酮和新兴真菌毒素如交链孢毒素、白僵菌素和恩镰孢菌素等暴露引起的胚胎发育毒性,以及以生物标志物如暴露标志物和效应标志物为基础的生物监测技术的研究现状.
Mycotoxins are toxic secondary metabolites produced by certain fungal species under specific conditions.Research has found that exposure to various fungal toxins can cause embryonic developmental toxicity,such as embryo arrest,abortion,and intrauterine fetal developmental delay.There are no systematic reports on the impact of exposure to fungal toxins during pregnancy on the toxicity of intrauterine fetal development and biological monitoring.Therefore,in order to prevent and reduce the harm of fungal toxins during pregnancy,this paper summarizes the research status of embryonic developmental toxicity,as well as the research status of biological monitoring technologies based on biomarkers such as exposure biomarkers and biomakers of effect,which are caused by traditional fungal toxins such as aflatoxin,deoxynivalenol,zearalenone,and emerging fungal toxins such as Alternaria toxins,beauverin,and enniatins.The aim of the paper is for construction of the healthy China.
韩小敏;叶金;纪剑;徐文静;吴宇;叶永丽;Rudolf KRSKA;孙秀兰;白莉
国家食品安全风险评估中心,北京 100022国家粮食和物资储备局科学研究院 粮油质量安全研究所,北京 100037江南大学 食品学院,江苏 无锡 214122维也纳自然资源与生命科学大学,生物分析与农业代谢组学研究所,农业生物技术系,奥地利,图尔恩 3430||贝尔法斯特女王大学,生物科学学院,全球食品安全研究所,英国,北爱尔兰 贝尔法斯特 BT9 5DL
轻工业
孕期传统和新兴真菌毒素胚胎发育毒性生物监测
pregnancytraditional and emerging mycotoxinembryo developmental toxicitybiological monitoring
《粮油食品科技》 2024 (004)
16-23 / 8
国家重点研发计划项目(2022YFE0137500);北京市自然科学基金面上项目(7212145) National Key Research and Development Program of China(No.2022YFE0137500);Beijing Natural Science Foundation Project(No.7212145)
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