水飞蓟素的提取及其生物活性研究进展OACSTPCD

The study summarized the effective components of Silybum marianum and the research progress related to its physiological activities in liver protection,anti-diabetes,cardiovascular protection,anti-cancer,and antioxidant aspects,providing theoretical references for the rational development and application of Silybum marianum.Relevant studies had found that silymarin primarily eliminated free radicals via its anti-lipid peroxidation activity,boosted liver glutathione(GSH)levels in the liver,and played a hepatoprotective role.It also protected kidneys by inhibiting the elevation in serum creatinine,uric acid,urea nitrogen,and urea levels.silymarin maintained normal blood sugar and insulin serum levels by increasing the expression of glucagon and insulin,thus achieving anti-diabetic effects.It exhibited anti-inflammatory property by inhibiting NF-κB regulator gene and COX-2 activity.Furthermore,silymarin alleviated dyslipidemia and cardiovascular dysfunction by promoting ribosomal RNAproduction,inducing cell regeneration,and eliminating free radicals.It also exerted anticancer effects through the activation of NF-κB associated pathways,inducing threonine phosphorylation,and degrading cyclin D1 protease.